TRIBECA, Manhattan — Emergency officials are on scene in Lower Manhattan where multiple people were injured, an FDNY spokesperson said.

It appears several people were hit by a Home Depot truck around Hudson Street and Chambers Street shortly after 3 p.m.

At least five people were hurt, sources said. At least two people were killed. They may have been on bicycles.

One person is in custody, police said. The person in custody was shot by police.

“A car just ran over 2 people and then crashed into a school bus,” one person on scene tweeted. “I see two dead bodies and citibikes on the floor destroyed.”