Bigger creatures should have more cancer risk. However, Elephants do not have high rates of cancer. They have some kind of protection.

* elephants have 20 extra duplicates of p53, a tumor suppressor gene.
* they also duplicate copies of the LIF gene, which encodes for leukemia inhibitory factor.

Elephant cells commit suicide at the first hint of abnormality.

Above – Lucy Reading-Ikkanda/Quanta Magazine

Biorxiv – A zombie LIF gene in elephants is up-regulated by TP53 to induce apoptosis in response to DNA damage (27 page PDF)